Is it safe to cross the border by bus?

Yes, tourist buses are the safest and most efficient method. Do not use random shared taxis at the border.

Can I use US dollars in Bolivia?

Keep some USD for emergencies or visa fees, but convert most of your cash to Bolivianos at a bank in Puno or La Paz for daily expenses.

Planning an Overland Trip from Peru to Bolivia

Cross the border via the Desaguadero or Kasani route after spending at least three days in Cusco to acclimate to the altitude. Take a direct tourist bus from Puno to La Paz to simplify immigration procedures and ensure you reach your destination in roughly 8 to 10 hours.

Acclimatize in Cusco/Puno. Do not rush. Spend at least 3 full days in Cusco (3,400m) or Puno (3,800m) before attempting the border crossing. Altitude sickness is real and can ruin your transit.
Book a Tourist Bus. Use a reputable company like Titicaca Bolivia or Transzela. Avoid public 'colectivos' for your first crossing; tourist buses handle the paperwork for you at the border and won't leave you stranded if the lines are long.
Prepare Your Documents. Ensure you have your passport, your PDI (the small paper slip given at entry to Peru), and any required visa documents for Bolivia printed out. Have $30 USD in clean, crisp bills ready for the Bolivia visa fee if you are a US citizen.
The Border Crossing. When the bus arrives at the Desaguadero border, keep your hand luggage with you at all times. Get your exit stamp from Peru, walk across the bridge, and get your entry stamp from Bolivia. Reboard the bus on the other side.

Is it safe to cross the border by bus?: Yes, tourist buses are the safest and most efficient method. Do not use random shared taxis at the border.
Can I use US dollars in Bolivia?: Keep some USD for emergencies or visa fees, but convert most of your cash to Bolivianos at a bank in Puno or La Paz for daily expenses.