Is it safe to drink the tap water?

In Panama City and Boquete, it is generally safe. On the islands like Bocas del Toro, stick to bottled or filtered water.

Do I need to carry cash?

Yes. While cards are accepted in cities, many small shops, taxis, and island vendors only take cash (US Dollars).

Planning a Panama Itinerary

Focus on three distinct regions: Panama City for urban history and the Canal, the Chiriquí Highlands for coffee and hiking, and either Bocas del Toro or the San Blas Islands for Caribbean beaches. Plan for 10 days to cover these core areas comfortably without spending your entire trip on internal transit.

Decide between islands. Choose Bocas del Toro if you want an established backpacker vibe, nightlife, and water taxis. Choose San Blas (Guna Yala) if you want remote, off-the-grid island camping with zero internet and traditional Guna culture.
Map out your logistics. Panama City is your hub. Use domestic flights (Air Panama) to reach David (for Boquete) or Bocas del Toro to save 8-10 hours of bus time per leg.
Balance the microclimates. Pack for both high-altitude cool weather in the mountains (Boquete) and intense tropical humidity on the coasts. You will need a rain shell for the mountains regardless of the season.
Book transport in advance. If you are traveling during the dry season (December–April), book your internal flights at least 4 weeks out, as these small planes fill up quickly.

Is it safe to drink the tap water?: In Panama City and Boquete, it is generally safe. On the islands like Bocas del Toro, stick to bottled or filtered water.
Do I need to carry cash?: Yes. While cards are accepted in cities, many small shops, taxis, and island vendors only take cash (US Dollars).