Is it safe to drink the water?

No. Only drink bottled or filtered water. Even for brushing teeth, use bottled water in rural areas.

Should I fly between cities?

Internal flights exist, but they are frequently delayed or cancelled due to weather. Stick to reliable bus lines for a more predictable schedule.

How to plan a 3-week trip to Bolivia

Spend 21 days focusing on a loop that starts and ends in La Paz, prioritizing altitude acclimatization before heading to the Salar de Uyuni. Use a mix of overnight buses for distance and private transfers for remote areas to maximize your time.

Acclimatize in La Paz. Spend your first 3 days in La Paz (3,640m) taking it easy. Do not plan strenuous hikes immediately. Use this time to explore the city markets and take the Mi Teleférico cable car system to adjust to the thin air.
Book your Uyuni tour in advance. Do not show up in Uyuni expecting to walk into a reliable tour agency. Book your 3-day Salt Flats excursion at least 2 weeks before arrival to ensure a reputable operator with well-maintained 4x4 vehicles.
Use buses for the main route. Use the 'Todo Turismo' bus line for the La Paz to Uyuni route. It is safer, more comfortable, and includes meals. For shorter distances, use local bus terminals, but always buy your tickets at the office an hour before departure.
Pack for four seasons. Bolivian weather changes by altitude. Expect daytime highs of 20°C and nighttime lows of -10°C in the desert. Always pack layers.

Is it safe to drink the water?: No. Only drink bottled or filtered water. Even for brushing teeth, use bottled water in rural areas.
Should I fly between cities?: Internal flights exist, but they are frequently delayed or cancelled due to weather. Stick to reliable bus lines for a more predictable schedule.