Is altitude sickness common?

Yes. La Paz and Uyuni are significantly above 3,000m. Plan to rest for the first 48 hours and consider altitude medication prescribed by your doctor.

Do I need to book internal flights in advance?

Yes, especially for the Rurrenabaque route. Flights are often small and sell out 2-3 weeks in advance during peak season.

A Two-Week Bolivia Itinerary: Mountains, Salt Flats, and Amazon

To see Bolivia in 14 days, prioritize the high-altitude Andes and the Amazon basin by flying between key hubs like La Paz and Rurrenabaque to save time. You will need to manage altitude acclimatization carefully for the first three days before heading to the Salar de Uyuni.

Acclimatize in La Paz. Spend your first 3 days in La Paz (3,640m). Do not book strenuous hikes immediately; use the Teleférico (cable car system) to explore the city and drink coca tea to manage altitude sickness.
Book a 3-day Salar de Uyuni tour. Book this locally in La Paz or Uyuni. Ensure the tour includes a professional driver and a 4x4 vehicle. Pack warm layers, as temperatures drop below freezing at night.
Fly to the Amazon. Do not take the bus from La Paz to Rurrenabaque; the 'Death Road' mountain pass takes 16+ hours. A 45-minute flight saves you a full day of travel.
Secure your visa documentation. Check the specific entry requirements for your nationality weeks in advance. Many travelers need to apply for a visa online and bring printed proof to the border or airport.

Is altitude sickness common?: Yes. La Paz and Uyuni are significantly above 3,000m. Plan to rest for the first 48 hours and consider altitude medication prescribed by your doctor.
Do I need to book internal flights in advance?: Yes, especially for the Rurrenabaque route. Flights are often small and sell out 2-3 weeks in advance during peak season.