Is it better to book direct or with an OTA like Expedia?

Always book directly through the airline's website. If there is a flight cancellation or change, dealing with a third-party agency is significantly more difficult.

Are layovers in Europe better than in the Middle East?

Middle Eastern layovers (Doha, Dubai, Abu Dhabi) are generally more comfortable with better facilities, but European routes (London, Frankfurt, Paris) may offer shorter total flight times depending on your U.S. departure city.

Finding the Best Flights from the USA to India

Book your tickets exactly 3 to 4 months in advance to secure the lowest fares. Use Google Flights to track prices and prioritize nonstop routes from hubs like SFO, EWR, or JFK to save time on long-haul transit.

Set your departure hub. Don't just check your local airport. It is often significantly cheaper to book a domestic positioning flight to a major gateway like New York (JFK/EWR), Chicago (ORD), San Francisco (SFO), or Washington D.C. (IAD) and buy a separate ticket from there.
Use the Google Flights calendar view. Enter your destination (e.g., DEL for Delhi or BOM for Mumbai) and click the date field to open the calendar. This immediately reveals price differences day-by-day. Aim for mid-week departures (Tuesday/Wednesday) to shave $150–$300 off your ticket.
Set a price alert. Once you have your preferred dates, toggle the 'Track prices' switch on Google Flights. You will receive an email the moment the price drops. Do not wait more than 24 hours to book once you see a price within your budget.
Choose your airline alliance. Prioritize Star Alliance (United/Air India) or SkyTeam (Delta/Air France) to accrue miles. For long-haul comfort, consider carriers like Qatar Airways or Emirates, though be prepared for a 3–5 hour layover in the Middle East.

Is it better to book direct or with an OTA like Expedia?: Always book directly through the airline's website. If there is a flight cancellation or change, dealing with a third-party agency is significantly more difficult.
Are layovers in Europe better than in the Middle East?: Middle Eastern layovers (Doha, Dubai, Abu Dhabi) are generally more comfortable with better facilities, but European routes (London, Frankfurt, Paris) may offer shorter total flight times depending on your U.S. departure city.